Pemphigus vulgaris and mucous membrane pemphigoid: Update on etiopathogenesis, oral manifestations and management

Introduction: The treatment of oral mucosal disorders must be based on an early and correct diagnosis. Pemphigus vulgaris (PV) and mucous membrane pemphigoid (MMP) are among the diseases that pose the greatest diagnostic difficulties for dentists, with scores of 7.35 and 8.03, respectively, on a scale from 0-10. Objective: To conduct a literature review on PV and MMP, and to summarize the case series involving more than two patients with these diseases. Material and Methods: A PubMed – Medline search was carried out, using the key words “pemphigus vulgaris” and “oral mucous membrane pemphigoid”. The search was limited to “case reports” and “dental journals”, and yielded a total of 122 articles on PV and 68 on MMP. The review considered only those accessible publications involving series of over two patients. Results: Seven articles on PV and 5 on MMP, involving series of over two patients, were finally included. Conclusions: A review has been made of the most recent literature on PV and MMP, documenting those series reporting over two patients.